Syntheses of apogalanthamine analogs as .ALPHA.-adrenergic blocking agents.
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چکیده
منابع مشابه
The pharmacology of beta-adrenergic blocking agents.
T HE endogenously released neurotransmitter substance, norepinephrine, or an injected sympathomimetic amine, ultimately exerts its actions on an organ system by combining with an area of the effector cell termed the adrenergic “receptor site.” That drugs and neural chemical mediators react with specific receptors in living tissues was suggested by Langley”” in 1905, who suggested that effector ...
متن کاملBeta-adrenergic blocking agents in heart failure.
Cardiac dysfunction in heart failure is widely recognized as a progressive process, regardless of the clinical signs and symptoms. An increase in cardiac sympathetic drive is one of the earliest neurohormonal responses occurring in patients with heart failure and may be one of the major causes of the progressive remodeling leading to the decline in myocardial function, and responsible for the p...
متن کاملPostischemic left ventricular dysfunction is abolished by alpha-adrenergic blocking agents.
OBJECTIVES We sought to evaluate the efficacy of alpha-adrenergic blocking agents in counteracting left ventricular (LV) dysfunction occurring after transient ischemia in humans. BACKGROUND The mechanisms underlying postischemic LV dysfunction are largely unknown. METHODS Percutaneous transluminal coronary angioplasty (PTCA) provides a clinical model of ischemia and reperfusion. In 50 patie...
متن کاملAnalogs of phosphatidylcholine: alpha-adrenergic antagonists from the renal medulla.
Antihypertensive polar renomedullary lipid (APRL), a conglomerate of 1-0-alkyl-2-acetoyl-glycero-3-phosphocholine analogs, ws tested in 4- to 6-week-old spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats using microcirculatory techniques. APRL (0.5 ug/ml), when added to the solution bathing the cremaster muscle, caused significant changes in the diameter, red blood cell v...
متن کاملEffects of adrenergic neurone blocking agents on guinea pig ileum.
Sharma and Rajapurkar (~) while studying the actions of adrenergic neurone blocking drugs on intestinal peristalsis observed that bretyliurn and xylocholine in bigger doses produced a stimulant response on the longitudinal moveme-nts of guinea pig ileum where as guanethidine had no stimulant action (unreported observations). Those observations are in consonance witb tbe observations of Boura an...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1977
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.25.3312